I became interested in reading this biography after hearing about interviews with Schenkar, who called Patricia Highsmith a sociopath. Patricia Highsmith is, of course, the author of many mid-20th century thrillers, the most famous being Strangers on a Train and The Talented Mr. Ripley. After reading the biography, I don’t really think Highsmith was a sociopath. I think she was fascinated with certain dark themes, but she strikes me as more of a social inept, perhaps partially on the autistic spectrum.
Highsmith was certainly a complex person of many contradictions. She was a lesbian misogynist, as contradictory as that sounds, who was a great womanizer in her younger years and was seldom faithful to any of her lovers. She was an outspoken anti-Semite who had Jewish lovers and a lot of Jewish friends. Known in later years as a recluse, she visited her neighbors every evening and corresponded with many people, as well as making an appearance whenever invited.
She certainly was a damaged person. She had a love-hate relationship with her mother for her entire life, blaming her for abandoning her briefly when she was young and for not divorcing her stepfather. She was a woman who always thought she should actually have been a man. A heavy drinker and smoker, she barely ate any food for years and was probably anorexic.
Her life was an interesting one. She did not seem to be a likable person and frequently behaved very badly. Yet, she had many sincerely devoted friends.
I was interested in this book but had some issues with its structure. Schenkar explains at the beginning that a chronological approach wouldn’t do Highsmith justice, so she approaches Highsmith’s life sort of organically. The problem I found with this approach was that after awhile I could not figure out what organizing principle is holding some of the chapters together. Sometimes they just seem to follow a stream of consciousness approach. It makes the information conveyed very repetitive and chronologically impossible to follow. Schenkar helpfully provides a chronology at the back of the book, along with about 100 pages of supplementary material, but by then I was exhausted and had no interest in exploring any of it.
Finally—this is a small quibble—I got irritated by Schenkar’s chapter naming. The table of contents shows only nine chapters in this very long book, but there are really forty-nine. That is because she actually names them Les Girls Part 1, Les Girls Part 2, and so on. Perhaps I’m being unfair, but I could just imagine Schenkar’s editor telling her she couldn’t have a 150-page chapter, which is the length of Les Girls, Parts 1–14. Such an approach does not strike me as being very imaginative.
What? Me Read? 
Miss Highsmith’s life does sound like an interesting read, but from the sounds of the way the book was written, I probably will not be reading it. I know a lot more about her from reading your review then I did before, and I think that will do for now!
It’s the second biography I have read lately that was organized by topic instead of chronologically, and I had the same complaint both times. This time, even, it seemed as if there was no reason to order it this way.